Porphyromonas gingivalis Outer Membrane Vesicles Promote Gingival Fibroblasts Senescence via IL21R‐AS1

P. gingivalis OMVs promote HGFs senescence SASP by the upregulation of IL21R-AS1, which acts as a ceRNA, mediating the miR-500a-3p/FBXW7 axis and contributes to the progression of periodontitis. These findings offer novel insights into the molecular mechanisms of OMVs-induced senescence and periodontitis.