Ru(II)‐Catalyzed C‐H Alkylation of Indoles at the C‐3 Position with Coumarin‐3‐Carboxylic Acids

Abstract A ruthenium(II)‐catalyzed C3‐selective C─H activation of indoles bearing a pyridyl or pyrimidine directing group and subsequent conjugated/decarboxylative addition to coumarin‐3‐carboxylic acids has been demonstrated. This protocol efficiently afforded a variety of coumarin‐containing indoles with excellent site selectivity, satisfactory product yields, and functional group tolerance.