医学
内科学
内分泌学
炎症
自噬
基因敲除
巨噬细胞
核受体
癌症研究
生物
转录因子
生物化学
细胞凋亡
体外
基因
作者
Feifei Li,Yixuan Wang,Shuai Chen,Jingmeng Liu,Xinrui Wu,Yipaerguli Maimati,Fenghua Ding,Xiao Qun Wang,Ying Shen,Qiujing Chen,Yunqi Li,Weifeng Shen,Ruiyan Zhang,Yang Dai,Lin Lu
标识
DOI:10.1093/eurheartj/ehaf241
摘要
This study demonstrates that Dax1 levels are increased in atherosclerotic plaques. Dax1 promotes atherosclerosis by interacting with TFEB to suppress autophagy and inhibiting LXRα for lipid transport in macrophage, indicating that Dax1 is a potential target for atherosclerosis.
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