感觉系统
感觉
转导（生物物理学）
基因敲除
离子通道
感知
生物物理学
神经科学
生物
化学
生物化学
受体
细胞凋亡
作者
Sampurna Chakrabarti,Jasmin Daniela Klich,Mohammed A. Khallaf,Amy E. Hulme,Oscar Sánchez-Carranza,Zuzanna M. Baran,Alice Rossi,Tzu-Lun Huang,Tobias T. Pohl,Raluca Fleischer,Carina Fürst,Annette Hammes,Valérie Bégay,Hanna Hörnberg,Rocio K. Finol‐Urdaneta,Kate Poole,Mirella Dottori,Gary R. Lewin
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2024-02-29
卷期号：383 (6686): 992-998
被引量：10
标识
DOI：10.1126/science.adl0495
摘要
Touch perception is enabled by mechanically activated ion channels, the opening of which excites cutaneous sensory endings to initiate sensation. In this study, we identify ELKIN1 as an ion channel likely gated by mechanical force, necessary for normal touch sensitivity in mice. Touch insensitivity in
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