食管癌
医学
内科学
白蛋白
淋巴细胞
胃肠病学
癌症
肿瘤科
病理
作者
Toru Aoyama,Itaru Hashimoto,Yukio Maezawa,Kentaro Hara,Keisuke Kazama,Keisuke Komori,Masakatsu Numata,Ayako Tamagawa,Momoko Fukuda,HARUHIKO CHO,Junya Morita,Seiichiro Yoshizawa,Keisuke Otani,Aya Kato,MIE TANABE,Masato Nakazono,Shinnosuke Kawahara,Takashi Oshima,Aya Saito,Norio Yukawa,Yasushi Rino
标识
DOI:10.21873/anticanres.16873
摘要
Background/Aim: Perioperative inflammation and the nutritional status affect both short- and long-term oncological outcomes in various malignancies. We clarified the clinical impacts of the CRP-albumin-lymphocyte (CALLY) index in patients with esophageal cancer who received curative treatment. Patients and Methods: The present study included 180 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters were compared between a high-fibrinogen group and a low-fibrinogen group. Results: The 3- and 5-year overall survival rates were 50.0% and 42.6%, respectively, in the CALLY index-low group, and 75.9% and 66.6% in the CALLY index-high group. The differences between the two groups were statistically significant (p<0.001). Univariate and multivariate analyses demonstrated that the CALLY index was an independent prognostic factor [hazard ratio=2.310, 95% confidence interval=1.416-3.767, p<0.001]. Similar results were observed in recurrence-free survival. When comparing the details of postoperative surgical complications, there was a significant difference in the incidence of anastomotic leakage. The incidence of anastomotic leakage was 40.2% in the CALLY index-low group, while it was 27.5% in the CALLY index-high group (p=0.030). Conclusion: The pretreatment CALLY index is one of the independent prognostic factors for esophageal cancer. The CALLY index might become a promising biomarker for the treatment and management of esophageal cancer.
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