吲哚试验
叶立德
戒指(化学)
重氮
化学
组合化学
四级碳
铵
反应条件
药物化学
立体化学
有机化学
催化作用
对映选择合成
作者
Shen Wang,Xiujing Lu,Yu Shen,Junjian Li,Ai‐Qun Jia,Shi Tang
标识
DOI:10.1021/acs.joc.3c02249
摘要
The formal cyclization strategy was generally used to construct azepino[4,5-b]indole. Herein, we reported a novel and expeditious protocol for the synthesis of quaternary carbon azepino[4,5-b]indole via ring expansion of ammonium ylide, which was formed by the reaction of tetrahydro-β-carbolines with the diazo compound. The easily available substrates, mild reaction conditions, and broad functional tolerance rendered this method a practical strategy that may significantly afford an efficient method of scaffold hopping in drug discovery.
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