再生(生物学)
脚手架
纳米线
锌
材料科学
细胞生物学
纳米技术
生物医学工程
医学
生物
冶金
作者
Yixin Zhang,Zixin Li,Bowen Guo,Qibo Wang,Liyuan Chen,Lisha Zhu,Ting Zhang,Ruoxi Wang,Weiran Li,Dan Luo,Yan Liu
出处
期刊:Small
[Wiley]
日期:2023-12-19
被引量:2
标识
DOI:10.1002/smll.202309230
摘要
Bone infection poses a major clinical challenge that can hinder patient recovery and exacerbate postoperative complications. This study has developed a bioactive composite scaffold through the co-assembly and intrafibrillar mineralization of collagen fibrils and zinc oxide (ZnO) nanowires (IMC/ZnO). The IMC/ZnO exhibits bone-like hierarchical structures and enhances capabilities for osteogenesis, antibacterial activity, and bacteria-infected bone healing. During co-cultivation with human bone marrow mesenchymal stem cells (BMMSCs), the IMC/ZnO improves BMMSC adhesion, proliferation, and osteogenic differentiation even under inflammatory conditions. Moreover, it suppresses the activity of Gram-negative Porphyromonas gingivalis and Gram-positive Streptococcus mutans by releasing zinc ions within the acidic infectious microenvironment. In vivo, the IMC/ZnO enables near-complete healing of infected bone defects within the intricate oral bacterial milieu, which is attributed to IMC/ZnO orchestrating M2 macrophage polarization, and fostering an osteogenic and anti-inflammatory microenvironment. Overall, these findings demonstrate the promise of the bioactive scaffold IMC/ZnO for treating bacteria-infected bone defects.
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