蛋白激酶B
赫拉
细胞凋亡
波形蛋白
癌症研究
吲哚试验
PI3K/AKT/mTOR通路
化学
上皮-间质转换
癌细胞
信号转导
细胞生物学
转移
生物
细胞
癌症
免疫学
生物化学
免疫组织化学
遗传学
作者
Zhen Xu,Yuan Yao,Jiaqi Liu,Caijing Li,Kejin Chen,Fang Wang,Ganpeng Li
出处
期刊:Anti-Cancer Drugs
[Ovid Technologies (Wolters Kluwer)]
日期:2024-01-23
卷期号:35 (4): 325-332
标识
DOI:10.1097/cad.0000000000001568
摘要
Apoptosis and epithelial-to-mesenchymal transition (EMT) are closely associated with tumor survival and metastasis. These are the basic events in tumor occurrence and progression. STK214947 is an indole alkaloid with a skeleton that is similar to that of indirubin. Indole alkaloids have attracted considerable attention because of their antitumor activity. However, the relationship between STK214947 and these basic events remains unknown. In this study, the effects of STK214947 on inducing apoptosis and reversing the EMT process in tumor cells were confirmed. Mild concentrations of STK214947 inhibited tumor cell migration by reversing EMT and significantly regulated the expression of EMT-related proteins, including Notch3, E-cadherin, N-cadherin and vimentin. In addition, STK214947 in high concentration could induce apoptosis by down-regulating Notch3, p-Akt/Akt, and NF-κB, and upregulating Caspase 3. These findings support the further development of STK214947 as a potential antitumor small molecule that targets Notch3 and Akt signal transduction in cancer.
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