化学
烷基化
催化作用
电泳剂
铜
亲电芳香族取代
有机化学
组合化学
作者
Wanting Fu,Jinfeng Tian,Yuan‐Li Ding,Xi Wang,Mei‐Yan Wang,Zikun Wang
标识
DOI:10.1021/acs.orglett.4c00475
摘要
A copper-catalyzed highly para-selective electrophilic aromatic alkylation of monosubstituted simple arenes has been accomplished. This method provides a practical platform for the transformation from simple commercial arenes to well-defined di- and multisubstituted aromatics with high added value. Control experiments and DFT calculations reveal that the achievement of the excellent site-selectivity is ascribed to the controlled deprotonation of the Wheland intermediates. Remarkably, the type of alkylating regent has been shown to have a significant impact on site-selectivity.
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