融合
低温电子显微
脂质双层融合
膜蛋白
融合蛋白
化学
蛋白质结构
生物物理学
计算生物学
膜
纳米技术
生物
生物化学
材料科学
重组DNA
语言学
基因
哲学
作者
Wenhao Cui,Yange Niu,Lei Chen
出处
期刊:Biochemistry
[American Chemical Society]
日期:2022-08-01
卷期号:62 (2): 196-200
被引量:3
标识
DOI:10.1021/acs.biochem.2c00319
摘要
Despite the resolution revolution of cryo-EM, structures of small membrane proteins (<80 kDa) are still understudied. These proteins are notoriously reluctant to structure determination by single-particle cryo-EM. Protein fusion might represent a plausible strategy to overcome such difficulties. This Perspective enumerates recent exemplary progress and discusses the future potential of the protein fusion strategy.
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