Unveiling the molecular legacy of transient insulin resistance: Implications for hepatic metabolic adaptability

While the health significance of transient insulin resistance is well established, the molecular processes that occur after such episodes are poorly understood. This study thus provides a circadian molecular paradigm for a later-in-life alteration of liver metabolic flexibility following a previous episode of insulin resistance and calls for particular attention to be paid to detecting transient episodes of insulin resistance as they occur in patients with gestational diabetes or stress-induced hyperglycemia. By extension, any transient exposure to compounds altering circadian rhythmicity, such as anti-depressants, might predispose to a compromised metabolic response to an unbalanced diet later in life.