A New Germacrane-Type Sesquiterpene Lactone from Salvia castanea

One new germacrane-type sesquiterpene lactone, named as salviatanolide A (1) was isolated from an ethanol extract of the whole plant of Salvia castanea.Its structure was elucidated by 1D and 2D-NMR and HRESIMS spectra, and its absolute configuration was determined by single crystal X-ray crystallography.The anti-Alzheimer's disease (AD) activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model.Compound 1 significantly delayed AD-like symptoms of worm paralysis phenotype, which may be potential to be served as anti-AD agent candidate.