癌症研究
生物
癌症
癌变
副作用(计算机科学)
浪费的
放射治疗
程序性细胞死亡
癌细胞
细胞内
恶病质
旁观者效应
脂质过氧化
免疫疗法
生物信息学
免疫系统
免疫学
医学
细胞生物学
内科学
氧化应激
细胞凋亡
内分泌学
生物化学
程序设计语言
遗传学
计算机科学
作者
Jiandong Diao,Yuanyuan Jia,Enyong Dai,Jiao Liu,Rui Kang,Daolin Tang,Leng Han,Yingjie Zhong,Lingjun Meng
标识
DOI:10.1186/s12943-024-01999-9
摘要
Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential to complement chemotherapy, immunotherapy, and radiotherapy in various cancer types. However, it can lead to side effects, including immune cell death, bone marrow impairment, liver and kidney damage, cachexia (severe weight loss and muscle wasting), and secondary tumorigenesis. In this review, we discuss the advantages and offer an overview of the diverse range of documented side effects. Furthermore, we examine the underlying mechanisms and explore potential strategies for side effect mitigation.
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