The challenge of molecular stratification in No Specific Molecular Profile endometrial cancer

These findings underscore the potential of ER loss and L1CAM overexpression as prognostic markers within the NSMP subgroup, supporting more personalized adjuvant strategies. Further research is needed to clarify the prognostic role of other alterations, such as ARID1A, specifically within NSMP tumors. PROSPERO registration number: CRD420250654207.