Pulmonary Vein Isolation by Pulsed-field Ablation Induces Less Neurocardiac Damage Than Cryoballoon Ablation

HomeCirculation: Arrhythmia and ElectrophysiologyVol. 16, No. 4Pulmonary Vein Isolation by Pulsed-field Ablation Induces Less Neurocardiac Damage Than Cryoballoon Ablation No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextPulmonary Vein Isolation by Pulsed-field Ablation Induces Less Neurocardiac Damage Than Cryoballoon Ablation Marc D. Lemoine, Celine Mencke, Moritz Nies, Julius Obergassel, Katharina Scherschel, Hartwig Wieboldt, Ruben Schleberger, Ilaria My, Laura Rottner, Julia Moser, Shinwan Kany, Jan-Per Wenzel, Fabian Moser, Leon Dinshaw, Paula Münkler, Bruno Reissmann, Feifan Ouyang, Christian Meyer, Stefan Blankenberg, Tanja Zeller, Larissa Fabritz, Andreas Rillig, Andreas Metzner and Paulus Kirchhof Marc D. LemoineMarc D. Lemoine Correspondence to: Marc Lemoine, MD Department of Cardiology, University Heart and Vascular Center, Hamburg, Martinistraße 52 20246, Hamburg, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-3799-7962 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Celine MenckeCeline Mencke Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Moritz NiesMoritz Nies Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Julius ObergasselJulius Obergassel https://orcid.org/0000-0002-3905-0203 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Katharina ScherschelKatharina Scherschel https://orcid.org/0000-0002-3237-140X Division of Cardiology/Angiology/Intensive Care, EVK Düsseldorf, cNEP, Cardiac Neuro- and Electrophysiology Research Consortium, Düsseldorf, Germany (K.S., C. Meyer). Institute for Neural and Sensory Physiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (K.S., C.Meyer). Search for more papers by this author , Hartwig WieboldtHartwig Wieboldt Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). University Center of Cardiovascular Sciences, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.W., T.Z., L.F.). Search for more papers by this author , Ruben SchlebergerRuben Schleberger https://orcid.org/0000-0003-3798-6427 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Ilaria MyIlaria My Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Laura RottnerLaura Rottner https://orcid.org/0000-0002-1389-8564 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Julia MoserJulia Moser Search for more papers by this author , Shinwan KanyShinwan Kany https://orcid.org/0000-0001-8113-733X Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Jan-Per WenzelJan-Per Wenzel https://orcid.org/0000-0002-6302-8671 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Fabian MoserFabian Moser Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Leon DinshawLeon Dinshaw https://orcid.org/0000-0002-1473-5716 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Paula MünklerPaula Münkler https://orcid.org/0000-0002-4104-0012 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Bruno ReissmannBruno Reissmann Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Feifan OuyangFeifan Ouyang https://orcid.org/0000-0001-5292-1758 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Christian MeyerChristian Meyer Division of Cardiology/Angiology/Intensive Care, EVK Düsseldorf, cNEP, Cardiac Neuro- and Electrophysiology Research Consortium, Düsseldorf, Germany (K.S., C. Meyer). Institute for Neural and Sensory Physiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (K.S., C.Meyer). Search for more papers by this author , Stefan BlankenbergStefan Blankenberg https://orcid.org/0000-0001-6488-2362 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). Search for more papers by this author , Tanja ZellerTanja Zeller Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). University Center of Cardiovascular Sciences, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.W., T.Z., L.F.). Search for more papers by this author , Larissa FabritzLarissa Fabritz https://orcid.org/0000-0002-9241-1733 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). University Center of Cardiovascular Sciences, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.W., T.Z., L.F.). Search for more papers by this author , Andreas RilligAndreas Rillig https://orcid.org/0000-0003-3457-0936 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author , Andreas MetznerAndreas Metzner Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Search for more papers by this author and Paulus KirchhofPaulus Kirchhof https://orcid.org/0000-0002-1881-0197 Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.D.L., C. Mencke, M.N., J.O., H.W., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K). German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany (M.D.L., C.M., M.N., J.O., R.S., I.M., L.R., S.K., J-P.W., F.M., L.D., P.M., B.R., F.O., S.B., T.Z., L.F., A.R., A.R., P.K.). Institute of Cardiovascular Sciences, University of Birmingham, UK (P.K.). Search for more papers by this author Originally published20 Mar 2023https://doi.org/10.1161/CIRCEP.122.011598Circulation: Arrhythmia and Electrophysiology. 2023;16FootnotesFor Sources of Funding and Disclosures, see page 242.Correspondence to: Marc Lemoine, MD Department of Cardiology, University Heart and Vascular Center, Hamburg, Martinistraße 52 20246, Hamburg, Germany. Email m.[email protected]deReferences1. Reddy VY, Dukkipati SR, Neuzil P, Anic A, Petru J, Funasako M, Cochet H, Minami K, Breskovic T, Sikiric I, et al. Pulsed field ablation of paroxysmal atrial fibrillation: 1-year outcomes of IMPULSE, PEFCAT, and PEFCAT II.JACC: Clin Electrophysiol. 2021; 7:614–627. doi: 10.1016/j.jacep.2021.02.014CrossrefMedlineGoogle Scholar2. Stewart MT, Haines DE, Miklavčič D, Kos B, Kirchhof N, Barka N, Mattison L, Martien M, Onal B, Howard B, et al. Safety and chronic lesion characterization of pulsed field ablation in a Porcine model.J Cardiovasc Electrophysiol. 2021; 32:958–969. doi: 10.1111/jce.14980CrossrefMedlineGoogle Scholar3. Lemoine MD, Fink T, Mencke C, Schleberger R, My I, Rottner L, Obergassel J, Muenkler P, Bergau L, Moser F, et al. Pulsed-field ablation based pulmonary vein isolation: acute safety and efficacy in a multi-center real world scenario.Heart Rhythm. 2022; 19:S91. doi: 10.1016/j.hrthm.2022.03.759CrossrefGoogle Scholar4. Scherschel K, Hedenus K, Jungen C, Lemoine MD, Rübsamen N, Veldkamp MW, Klatt N, Lindner D, Westermann D, Casini S, et al. Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation.Sci Transl Med. 2019; 11:e00v7770. doi: 10.1126/scitranslmed.aav7770CrossrefGoogle Scholar5. Scherschel K, Hedenus K, Jungen C, Münkler P, Willems S, Anwar O, Klatt N, Eickholt C, Meyer C. Impact of the ablation technique on release of the neuronal injury marker S100B during pulmonary vein isolation.Europace. 2020; 22:1502–1508. doi: 10.1093/europace/euaa159CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails April 2023Vol 16, Issue 4 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCEP.122.011598PMID: 36938715 Originally publishedMarch 20, 2023 Keywordscardiomyocytesatrial fibrillationpulmonary vein isolationirreversible electroporation therapycatheter ablationPDF download Advertisement SubjectsAtrial FibrillationAutonomic Nervous SystemBiomarkers