吡唑酮类
化学
组合化学
催化作用
相容性(地球化学)
有机化学
化学工程
工程类
作者
Bin Liu,Tao Qin,Yang Liu
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2023-08-22
卷期号:34 (19): 2336-2340
摘要
Abstract An efficient and general method for defluorinative O-arylation of pyrazolones has been successfully developed under metal-free conditions. This methodology allows for the synthesis of desired products by using a wide range of pyrazolones and polyfluoroarenes as starting materials. The compatibility of various substrates was demonstrated, ensuring the applicability of this method. Furthermore, the synthesis of the target compounds at a gram scale and the ability to perform late-stage modifications highlight the potential of this approach in preparative pharmaceutical synthesis and organofluorine chemistry.
科研通智能强力驱动
Strongly Powered by AbleSci AI