目标2
上睑下垂
炎症体
炎症
半胱氨酸蛋白酶1
先天免疫系统
免疫学
生物
传染病(医学专业)
背景(考古学)
免疫系统
分泌物
疾病
医学
病理
古生物学
生物化学
作者
Fan Zhang,Rui Chen,Yin Wu,Xin Xie,Shan Wang,Chunbo Hao
出处
期刊:Viral Immunology
[Mary Ann Liebert]
日期:2023-09-01
卷期号:36 (7): 438-448
被引量:3
标识
DOI:10.1089/vim.2023.0044
摘要
Both absent in melanoma 2 (AIM2) and interferon-inducible protein 16 (IFI16) are intracellular innate immune receptors that recognize double-stranded DNA released during pathogenic infection, leading to the assembly of the inflammasome. The assembly of the inflammasome results in the secretion of bioactive interleukin (IL)-1β and IL-18 and induces cell death through an inflammatory process called pyroptosis. Although the AIM2 inflammasome is generally harmful in the context of some aseptic inflammatory illnesses, it plays a protective role in infectious diseases. During inflammatory processes, there is competition between IFI16 and AIM2. In this review, we explore the impacts of IFI16 and AIM2 in infectious disease and aseptic inflammation, respectively, and how they compete.
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