自愈水凝胶
透明质酸
软骨发生
软骨
明胶
再生(生物学)
生物粘附
生物医学工程
肿胀 的
材料科学
生物材料
脚手架
细胞外基质
组织工程
化学
高分子化学
解剖
纳米技术
细胞生物学
药物输送
生物化学
复合材料
医学
生物
作者
Huangrong Zhu,Fengling Liu,Xinrang Zhai,Zhicheng Tong,Huimin Li,Wei Dong,Wei Wei,Chong Teng
标识
DOI:10.1016/j.bbrc.2023.09.060
摘要
With the increasing incidence of knee osteoarthritis (KOA), the reparation of cartilage defects is gaining more attention. Given that tissue integration plays a critical role in repairing cartilage defects, tissue adhesive hydrogels are highly needed in clinics. We constructed a biomacromolecule-based bioadhesive matrix hydrogel and applied it to promote cartilage regeneration. The hydrogel was composed of methacrylate gelatin and N-(2-aminoethyl)-4-(4-(hydroxymethyl)-2-methoxy-5-nitroso) butyl amide modified hyaluronic acid (HANB). The methacrylate gelatin provided a stable hydrogel network as a scaffold, and the HANB served as a tissue-adhesive agent and could be favorable for the chondrogenesis of stem cells. Additionally, the chemically modified HA increased the swelling ratio and compressive modulus of the hydrogels. The results of our in vitro study revealed that the hydrogel was compatible with bone marrow stromal cells. In vivo, the hyaluronic-acid-containing hydrogels were found to promote articular cartilage regeneration in the defect site. Therefore, this biomaterial provides promising potential for cartilage repair.
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