免疫系统
免疫学
免疫
接种疫苗
病毒学
疫苗试验
生物
异源的
获得性免疫系统
抗体
生物化学
基因
作者
Yuxin Chen,Tiantian Zhao,Lin Chen,Guozhi Jiang,Yu Geng,Wanting Li,Shengxia Yin,Yue Tao,Jun Ni,Qiuhan Lu,Mingzhe Ning,Chao Wu
出处
期刊:Research Square - Research Square
日期:2023-09-29
标识
DOI:10.21203/rs.3.rs-3325813/v1
摘要
Abstract The inactivated whole-virion vaccine, CoronaVac, is one of the most widely used coronavirus disease 2019 (COVID-19) vaccines worldwide. There is a paucity of data indicating the durability of the immune response and the impact of immune imprinting induced by CoronaVac upon Omicron breakthrough infection. In this prospective cohort study, 41 triple-dose CoronaVac recipients and 14 unvaccinated individuals were recruited and the anti-SARS-CoV-2 adaptive responses were analyzed before and post Omicron BA.5 infection. Twelve months after the third CoronaVac vaccination, spike-specific antibody and cellular responses were detectable in most vaccinees. BA.5 infection significantly augmented the magnitude, cross-reactivity and durability of serum neutralization activities, Fc-mediated phagocytosis, and nasal spike-specific IgA responses, memory B cells, memory CD4 + T cells, and memory CD8 + T cells for both the ancestral strain and Omicron subvariants, compared to unvaccinated individuals. Notably, the increment in BA.5-specific immunity after breakthrough infection was consistently higher than for the ancestral strain, suggesting no evidence of immune imprinting. Immune landscape analyses showed vaccinated individuals have better synchronization of multiple immune components than unvaccinated individuals upon heterologous SARS-CoV-2 infection. Our data provides detailed insight into the protective role of inactivated COVID-19 vaccine in shaping humoral and cellular immune responses to heterologous Omicron infection. Trial registration ClinicalTrials.gov NCT05680896
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