斑马鱼
泛素
先天免疫系统
生物
细胞生物学
磷酸化
受体
遗传学
基因
作者
Xiaoyun Chen,Sijia Fan,Chunchun Zhu,Qian Liao,Jinhua Tang,Guangqing Yu,Xiaolian Cai,Gang Ouyang,Wuhan Xiao,Xing Liu
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2022-09-15
卷期号:209 (6): 1165-1172
被引量:1
标识
DOI:10.4049/jimmunol.2100983
摘要
The signaling adaptor MAVS is a critical determinant in retinoic acid-inducible gene 1-like receptor signaling, and its activation is tightly controlled by multiple mechanisms in response to viral infection, including phosphorylation and ubiquitination. In this article, we demonstrate that zebrafish sirt5, one of the sirtuin family proteins, negatively regulates mavs-mediated antiviral innate immunity. Sirt5 is induced by spring viremia of carp virus (SVCV) infection and binds to mavs, resulting in attenuating phosphorylation and ubiquitination of mavs. Disruption of sirt5 in zebrafish promotes survival ratio after challenge with SVCV. Consistently, the antiviral responsive genes are enhanced, and the replication of SVCV is diminished in sirt5-dificient zebrafish. Therefore, we reveal a function of zebrafish sirt5 in the negative regulation of antiviral innate immunity by targeting mavs.
科研通智能强力驱动
Strongly Powered by AbleSci AI