瓜氨酸化
瓜氨酸
化学
翻译后修饰
生物相容性材料
生物物理学
生物化学
精氨酸
表面改性
化学改性
硼
组合化学
酶
氨基酸
有机化学
生物
医学
生物医学工程
物理化学
作者
Hailong Zhao,Aidong Shan,Yunshi Liang,Haiting Wu,Ying He,Huihong Chen,Jiaxin Zeng,Jiangyong Gu,Jianping Shen,Hong Qiu,Jing Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-08-23
卷期号:24 (34): 6351-6355
标识
DOI:10.1021/acs.orglett.2c02722
摘要
Protein citrullination is one type of protein post-translational modification. Previous methods entail the use of a strongly acidic condition (pH <1), which impedes its exploration under physiological and pathological conditions. Here, we developed a biocompatible method based on o-boron-assisted citrulline modification. We demonstrated that this method enables selective and mainly irreversible modification of citrulline residues under neutral conditions. We expect that it will provide a valuable tool for the study of protein citrullination.
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