单宁酸
伤口愈合
复合数
皮肤刺激
材料科学
聚乙烯醇
肿胀 的
壳聚糖
自愈水凝胶
体内
生物医学工程
复合材料
化学
医学
外科
高分子化学
生物化学
有机化学
生物技术
皮肤病科
生物
作者
Hemant Singh,Abhijit Dan,Bhawana Kumari,Hitendu Dave,Nitesh Parsaila,Archana Navale,Zenab Darban,Indu Yadav,Prateek Goyal,Superb K. Misra,Syed Shahabuddin,Shabir Hassan,Mukesh Dhanka
出处
期刊:Biomaterials advances
[Elsevier BV]
日期:2024-11-01
卷期号:164: 213983-213983
标识
DOI:10.1016/j.bioadv.2024.213983
摘要
The effective management of deep skin wounds remains a significant healthcare challenge that often deteriorates with bacterial infection, oxidative stress, tissue necrosis, and excessive production of wound exudate. Current medical approaches, including traditional wound dressing materials, cannot effectively address these issues. There is a great need to engineer advanced and multifunctional wound dressings to address this multifaceted problem effectively. Herein, a rationally designed composite cryogel composed of a Copper Metal-Organic Framework (Cu-MOF), tannic acid (TA), polyvinyl alcohol (PVA), and zein protein has been developed by freeze-thaw technique. Cryogels display a remarkable swelling capacity attributed to their interconnected microporous morphology. Moreover, dynamic mechanical behaviour with the characteristics of potent antimicrobial, antioxidant, and biodegradation makes it a desirable wound dressing material. It was further confirmed that the material is highly biocompatible and can release TA and copper ions in a controlled manner. In-vivo skin irritation in a rat model demonstrated that composite cryogel did not provoke any irritation/inflammation when applied to the skin of a healthy recipient. In a deep wound model, the composite cryogel significantly accelerates the wound healing rate. These findings highlight the multifunctional nature of composite cryogels and their promising potential for clinical applications as advanced wound dressings.
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