微生物
过氧化氢
次氯酸
纳米尺度
化学
纳米技术
金属
材料科学
细菌
光化学
有机化学
生物
遗传学
作者
Annie Y. Vargas,M. Aswad Ali,Nehal A. Mazumder,Gitanjali M. Kohli,Miroslava Zaborska,Tyler Sons,Michelle Garnett,Ishani M. Senanayake,Boyd M. Goodson,José M. Vargas-Muñiz,Amber Pond,Philip J. Jensik,Michael E. Olson,Scott D. Hamilton-Brehm,Punit Kohli
出处
期刊:Science Advances
[American Association for the Advancement of Science]
日期:2024-08-02
卷期号:10 (31)
被引量:1
标识
DOI:10.1126/sciadv.ado5555
摘要
Because of the decreasing supply of new antibiotics, recent outbreaks of infectious diseases, and the emergence of antibiotic-resistant microorganisms, it is imperative to develop new effective strategies for deactivating a broad spectrum of microorganisms and viruses. We have implemented electrically polarized nanoscale metallic (ENM) coatings that deactivate a wide range of microorganisms including Gram-negative and Gram-positive bacteria with greater than 6-log reduction in less than 10 minutes of treatment. The electrically polarized devices were also effective in deactivating lentivirus and Candida albicans . The key to the high deactivation effectiveness of ENM devices is electrochemical production of micromolar cuprous ions, which mediated reduction of oxygen to hydrogen peroxide. Formation of highly damaging species, hydroxyl radicals and hypochlorous acid, from hydrogen peroxide contributed to antimicrobial properties of the ENM devices. The electric polarization of nanoscale coatings represents an unconventional tool for deactivating a broad spectrum of microorganisms through in situ production of reactive oxygenated and chlorinated species.
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