Pharmacodynamic Activity of [ 18 F]-Fluorthanatrace Poly(ADP-ribose) Polymerase Positron Emission Tomography in Patients With BRCA1/2 -Mutated Breast Cancer Receiving Talazoparib

We conclude that [¹⁸F]FTT can image target engagement by PARPi, but larger studies are needed to determine whether [¹⁸F]FTT uptake can predict response to PARPi and whether uptake of [¹⁸F]FTT in bone marrow may be an early predictor of hematologic toxicity.