毒力
肺炎克雷伯菌
微生物学
抗生素耐药性
生物
菌血症
医学微生物学
肺炎
病菌
抗药性
病毒学
抗生素
铜绿假单胞菌
美罗培南
粘菌素
多重耐药
亚胺培南
抗菌剂
克雷伯菌
医学
基因
遗传学
大肠杆菌
内科学
作者
Claire Hennequin,Franck Robin
标识
DOI:10.1007/s10096-015-2559-7
摘要
Klebsiella pneumoniae is responsible for a wide range of infections, including urinary tract infections, pneumonia, bacteremia, and liver abscesses. In addition to susceptible clinical isolates involved in nosocomial infections, multidrug-resistant (MDR) and hypervirulent (hvKP) strains have evolved separately in distinct clonal groups. The rapid geographic spread of these isolates is of particular concern. However, we still know little about the virulence of K. pneumoniae except for hvKP, whose secrets are beginning to be revealed. The treatment of K. pneumoniae infections is threatened by the emergence of antimicrobial resistance. The dissemination of resistance is associated with genetic mobile elements, such as plasmids that may also carry virulence determinants. A proficient pathogen should be virulent, resistant to antibiotics, and epidemic. However, the interplay between resistance and virulence is poorly understood. Here, we review current knowledge on the topic.
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