DefensePredictor: A machine learning model to discover prokaryotic immune systems

strains, we predicted hundreds of previously unknown systems and experimentally validated 42 of them. Analysis of 1000 diverse prokaryotic genomes identified nearly 3000 protein clusters lacking homology to known systems, revealing a vast, uncharacterized defense repertoire. DefensePredictor will facilitate the comprehensive discovery of antiphage defense systems, which promises to reveal additional connections between prokaryotic and eukaryotic immunity and accelerate biotechnology development.