基底前脑
基底核
胆碱能神经元
葡萄孢霉素
病变
神经科学
胆碱能的
胆碱乙酰转移酶
海马体
失忆症
内科学
内分泌学
生物
心理学
医学
细胞生物学
病理
蛋白激酶C
精神科
磷酸化
作者
T. Nabeshima,Shin-ichi Ogawa,Hiroyuki Nishimura,Kazuyuki Fuji,Tsutomu Kameyama,Yasuo Sasaki
出处
期刊:PubMed
日期:1991-05-01
卷期号:257 (2): 562-6
被引量:12
摘要
Alzheimer's disease is characterized by the loss of cholinergic neurons in the nucleus basalis of Meynert and by a primary loss of memory function. Since staurosporine has been reported to induce differentiation in human neuroblastoma cells in vitro, we studied the effects of staurosporine on the amnesia induced by basal forebrain-lesion in rats. Staurosporine (0.05 and 0.1 mg/kg intraperitoneal) attenuated the impaired performance of water maze and passive avoidance tasks, even though the drug administration began 2 weeks after the lesion. Moreover, staurosporine (0.1 mg/kg) partially reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex induced by basal forebrain-lesion. These results suggest that staurosporine attenuates impairment of learning through reversal of damage to cholinergic neurons induced by basal forebrain-lesion. This evidence indicates that neurotrophic factor-like substances may be used in novel therapeutic approaches to Alzheimer's disease.
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