医学
类风湿性关节炎
甲氨蝶呤
安慰剂
内科学
毒性
胃肠病学
关节炎
口炎
青霉胺
病理
替代医学
作者
Daniel E. Furst,R Koehnke,Leon F. Burmeister,Johannes Köhler,Innes Cargill
出处
期刊:PubMed
日期:1989-03-01
卷期号:16 (3): 313-20
被引量:73
摘要
Forty-six patients with recalcitrant rheumatoid arthritis entered a trial encompassing a 2-week inpatient period plus a 16-week, randomized double blind, parallel study comparing placebo, 5 mg/m2 and 10 mg/m2 oral weekly methotrexate (MTX). An additional 6 patients, given 20 mg/m2 MTX, contributed to the toxicity, but not the efficacy analysis. All patients had "failed" either gold or D-penicillamine. A linear dose response relationship (placebo vs 5 mg/m2 vs 10 mg/m2) was found for 5 of 11 outcome variables: patient pain and patient global scale, physician global scale, joint tenderness count and activity of daily living scale (p less than 0.05 for each). Gastrointestinal toxicity (p = 0.002), dyspepsia (p less than 0.03) and stomatitis (p less than 0.09) occurred more commonly with MTX, and a general trend, although not significant, was found toward a dose toxicity relationship.
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