Modulatory effect of Ganoderma lucidum polysaccharides on serum antioxidant enzymes activities in ovarian cancer rats

In the present study, we isolated polysaccharides from Ganoderma lucidum and investigated its effect on serum antioxidant enzymes activity in ovarian cancer rats to explore the mechanism underlying the pharmacological anti-cancer activity of the polysaccharides. Rats were grouped into the control, model and polysaccharides-treated groups. After experiment ended, serum antioxidant enzymes activity in rats were measured. Results showed that polysaccharides from G. lucidum significantly reduced MDA production and increased serum antioxidant enzymes activity. These results suggest that the antioxidant activity of polysaccharides from G. lucidum might be benefical towards ovarian cancer therapy.