CD4/CD8 ratio: an emerging biomarker for HIV

In The Lancet HIV Cristina Mussini and colleagues 1 Mussini C Lorenzini P Cozzi-Lepri A et al. for the Icona Foundation Study GroupCD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV. 2015; (published online Feb 6.)http://dx.doi.org/10.1016/S2352-3018(15)00006-5 Google Scholar shed new light on the ratio of CD4 cells to CD8 cells, an old biomarker that might prove to be particularly useful as clinicians grapple with a new range of HIV-associated diseases. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort studyFew patients had normalised CD4/CD8 ratios, even though they had viral suppression. Low ratios were associated with increased risk of serious events and deaths. The CD4/CD8 ratio could be used by clinicians to identity patients at risk of non-AIDS-related events. Full-Text PDF