葡萄糖醛酸化
细胞色素P450
葡萄糖醛酸转移酶
UGT2B7型
化学
药物代谢
基因亚型
CYP3A4型
生物化学
功能(生物学)
酶
药理学
生物
微粒体
细胞生物学
基因
作者
Yuji Ishii,Shuso Takeda,Hideyuki Yamada
标识
DOI:10.3109/03602530903208579
摘要
Drug oxidation and conjugation mediated by cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) have long been considered to take place separately. However, our recent studies have suggested that CYP3A4 specifically associates with UGT2B7 and alters the regioselectivity of morphine glucuronidation. This observation strongly supports the view that there is functional cooperation between P450 and UGT to facilitate multistep drug metabolism. In recent years, accumulating evidence has suggested an interaction between UGT isoforms or between P450 and UGTs and a change in UGT function by protein-protein association. In this review, we summarize these interactions and discuss their relevance to UGT function.
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