Development and Characterization of Novel Medicated Nanofibers Against Periodontitis.
静电纺丝
材料科学
化学工程
作者
Deeksha Joshi,Tarun Garg,Amit K. Goyal,Goutam Rath
出处
期刊:Current Drug Delivery [Bentham Science] 日期:2014-12-05卷期号:12 (5): 564-577被引量:13
标识
DOI:10.2174/1567201812666141205131331
摘要
Periodontitis is an inflammatory disease of gums involving degeneration of periodontal
ligaments, creation of periodontal pocket and resorption of alveolar bone, thus disrupting the support
structure of teeth causing their loosening and finally removal. Since this disease is mainly confined to
the periodontal pocket, so site specific drug delivery of an antibiotic is the best suitable option. This
also eradicates the demerits of oral dosing like low drug concentration reaching the target site and the
various systemic side effects. In the present work, an efficient and easy technique of electrospinning
has been used to develop non-woven drug loaded and biodegradable nanofiber patch with inbuilt
property of high surface area to volume ratio. Hyaluronic acid (HA) has been used specifically as the polymer since it
possesses remarkable properties like providing an extracellular matrix supporting tissue regeneration, anti-inflammation
and mucoadhesion. A blend of this natural polymer with another polymer (Polyvinyl alcohol) has been tried since HA
alone cannot be electrospun efficiently as it shows very high viscosity at very low polymer concentration. The developed
formulation presented controlled release behavior with good mucoadhesive strength. The in vivo studies confirmed the
maintenance of minimum inhibitory concentration (MIC) over an extended period of time in addition to a significant antiinflammatory
effect. All these observations suggested that the above formulation forms a stable intra periodontal pocket
drug delivery system.