生物
后转座子
群体特异性抗原
基因
基因组
同源(生物学)
遗传学
基因亚型
泛素
计算生物学
细胞生物学
转座因子
作者
Mónica Campillos,Tobias Doerks,Parantu K. Shah,Peer Bork
标识
DOI:10.1016/j.tig.2006.09.006
摘要
In a genome-wide analysis, we have identified 85 human genes encoding 103 protein isoforms that resemble retroviral Gag proteins. These genes were domesticated from retrotransposons in at least five independent events during vertebrate evolution and were subsequently duplicated further in mammals. Structural insights into the mammalian proteins can be inferred by homology to Gag from viruses such as HIV; in turn, the cellular roles of the mammalian Gag homologs, such as apoptosis-related functions and binding to ubiquitin ligases, might hint at further functionality of viral Gag itself.
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