溶细胞素
细胞毒性
微生物学
生物
毒素
毒力
病菌
拉伤
梭菌
毒力因子
病毒学
细菌
体外
基因
遗传学
解剖
作者
Daniel E. Voth,Octavio Martínez,Jimmy D. Ballard
标识
DOI:10.1111/j.1574-6968.2006.00287.x
摘要
Clostridium sordellii is an emerging human pathogen and frequent contaminant of cadaver-derived tissue transplant material. Herein, we provide data suggesting the potential for severe C. sordellii-associated disease may be dictated by whether the specific strain produces lethal toxin (TcsL) or sordellilysin (SDL), a cholesterol-dependent cytolysin. The virulence factor profiles of 14 C. sordellii isolates were determined, and culture supernatant from six of the isolates was found to be cytotoxic to mammalian cells; yet, only one of these strains conferred cytotoxicity via production of TcsL. Cytotoxicity of TcsL− strains correlated with the production of sordellilysin, which was also recognized by an antiperfringolysin O antibody. However, supernatant from TcsL+, SDL− strains demonstrated a lower LD50 relative to TcsL−, SDL+ strains, suggesting the potential for severe C. sordellii-associated disease may be determined by the particular strain colonizing the host.
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