溶解
溶解度
化学
环糊精
塞来昔布
水溶液
核化学
包裹体(矿物)
溶解试验
有机化学
矿物学
生物化学
生物制药分类系统
作者
Vivek Ranjan Sinha,R. Anitha,Soma Ghosh,Amita,Rachana Kumria,Jayant Rajaram Bhinge,Manoj Kumar
出处
期刊:Acta Pharmaceutica
[De Gruyter]
日期:2007-03-01
卷期号:57 (1): 47-60
被引量:12
标识
DOI:10.2478/v10007-007-0004-x
摘要
Physicochemical characterization and in vitro dissolution behaviour of celecoxib-β-cyclodextrin inclusion complexes In this study, attempts were made to investigate the effects of β-cyclodextrin (β-CD) on the aqueous solubility and dissolution rate of celecoxib. Inclusion complexes were prepared by the kneading method and characterized by SEM, NMR, IR, DSC, and X-ray powder diffraction. Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug, indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
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