Effects of anticonvulsants and other agents on seizures induced by intracerebral l-glutamate

Convulsions induced in mice by intracerebral injection of l-glutamate were antagonized by phenytoin, phenobarbital, chlordiazepoxide and valproic acid. Trimethadione had only a small effect at the dose used, and ethosuximide was ineffective. The profile of interaction of glutamate with these antiepileptic agents resembles that of ouabain, and differs considerably from the profiles of other convulsants previously tested. However, muscimol had a small potentiating effect on glutamate but not on ouabain. Neither l-glutamic acid diethyl ester nor l-nuciferine significantly altered the convulsive response to glutamate.