Lanthanide metal–organic Framework Fluorescent Sensor for the Detection of Furazolidone in Tap Water and Animal Feed

The illegal use of furazolidone (FZD) in livestock and aquaculture results in FZD residues in related products, posing significant health risks such as carcinogenicity and teratogenicity. Accordingly, there is an urgent necessity to develop advanced analytical sensors for the detection of FZD residues. In this study, a Ln-MOF fluorescent sensor (HNU-104) was fabricated for the rapid detection of FZD, and it maintains structural stability in solutions with pH values ranging from 3 to 11. The limit of detection (LOD) for the FZD was found to be 37.3 ppb. For the analysis of actual samples, the spiked recovery rate ranged from 95.76% to 108.62%, and the relative standard deviation (RSD) was less than 0.10%. Furthermore, the sensing mechanism study indicates that fluorescence quenching is caused by the synergistic effects of the inner filter effect (IFE) and photoinduced electron transfer (PET). This work provides a robust Ln-MOF-based platform for the rapid and highly selective detection of FZD, showing great potential for applications in food safety analysis.