Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status

AIP and its obesity-related derivatives (particularly AIP-CVAI) exhibited significant positive associations with incident CVD risk. The strength of these associations dynamically influenced with cumulative changes in these metrics and significantly modified by diabetic status. Comprehensive analysis using weighted quantile sum and mediation models revealed that cumulative glucose effect partially mediated these associations, while sustained exposure to triglycerides and obesity emerged as primary drivers.