化学
废止
环己酮
催化作用
取代基
药物化学
烷基
有机化学
铜
作者
Haitao Yang,Suqing Zhou,Dan-Mei Chen,Zi-Jun Hu,Xiao-Qi Qiang,Xiaoqing Song,Sheng Tan,Wei-Hua Jiang,Yong-Qiang Sun,Chun-Bao Miao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-01-27
卷期号:25 (5): 838-842
标识
DOI:10.1021/acs.orglett.3c00003
摘要
A copper-catalyzed annulation of O-acyl oximes with cyclic 1,3-diones has been developed for the concise synthesis of 7,8-dihydroindolizin-5(6H)-ones and cyclohexanone-fused furans through the substituent-controlled selective radical coupling process. 2-Alkyl cyclic 1,3-diones undergo C–C radical coupling, while 2-unsubstituted cyclic 1,3-diones undergo C–O radical coupling.
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