XBP1 facilitating NF-κB-p65 nuclear translocation promotes macrophage-originated sterile inflammation via regulating MT2 transcription in the ischemia/reperfusion liver

XBP1, most conserved transcription factor of endoplasmic reticulum (ER) stress, plays important roles in physiological and pathological settings and has profound effects on disease progression and prognosis, so it's necessary to investigate XBP1 in macrophage-originated sterile inflammation during liver ischemia/reperfusion injury (IRI). Macrophage XBP1 expression and liver injury are analyzed in patients undergoing ischemia-related hepatectomy.