生物
甲状腺
谷氨酸的
激素
甲状腺激素受体
神经传递
兴奋性突触后电位
抑制性突触后电位
神经科学
内科学
内分泌学
谷氨酸受体
受体
遗传学
医学
作者
Daniel R. Hochbaum,Lauren Hulshof,Amanda Urke,Wengang Wang,Alexandra C. Dubinsky,Hannah C Farnsworth,Richard Hakim,Sherry Lin,Giona Kleinberg,Keiramarie Robertson,Canaria Park,Alyssa Solberg,Yechan Yang,Caroline Baynard,Naeem Nadaf,Celia Beron,Allison E. Girasole,Lynne Chantranupong,Marissa D. Cortopassi,Shannon Prouty
出处
期刊:Cell
[Cell Press]
日期:2024-08-22
卷期号:187 (20): 5679-5697.e23
被引量:34
标识
DOI:10.1016/j.cell.2024.07.041
摘要
Animals adapt to environmental conditions by modifying the function of their internal organs, including the brain. To be adaptive, alterations in behavior must be coordinated with the functional state of organs throughout the body. Here, we find that thyroid hormone-a regulator of metabolism in many peripheral organs-directly activates cell-type-specific transcriptional programs in the frontal cortex of adult male mice. These programs are enriched for axon-guidance genes in glutamatergic projection neurons, synaptic regulatory genes in both astrocytes and neurons, and pro-myelination factors in oligodendrocytes, suggesting widespread plasticity of cortical circuits. Indeed, whole-cell electrophysiology revealed that thyroid hormone alters excitatory and inhibitory synaptic transmission, an effect that requires thyroid hormone-induced gene regulatory programs in presynaptic neurons. Furthermore, thyroid hormone action in the frontal cortex regulates innate exploratory behaviors and causally promotes exploratory decision-making. Thus, thyroid hormone acts directly on the cerebral cortex in males to coordinate exploratory behaviors with whole-body metabolic state.
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