A Continuous Flow Process for the Defluorosilylation of HFC-23 and HFO-1234yf

High Resolution Image Download MS PowerPoint Slide A continuous flow process has been developed for the defluorosilylation of trifluoromethane (HFC-23) and 2,3,3,3-tetrafluoropropene (HFO-1234yf) through reaction with lithium silanide reagents under inert conditions. Design of experiment optimization improved process conditions, including productivity, yields, reduction of solvent use, and gas destruction. The small chain fluorinated organosilane products R 3 SiCF 2 H and R 3 SiCH 2 C(F)═CF 2 were competent nucleophiles in the fluoride-catalyzed difluoromethylation of aldehydes, and trifluoroallylation of aldehydes, ketones, and imines.