噬菌体
人体净化
食源性病原体
抗生素
生物技术
微生物学
食品
病菌
污染
受污染的食物
医学
食品微生物学
食品药品监督管理局
生物
机会性病原体
广谱
隐藏和查找
纳米技术
噬菌体疗法
致病菌
抗感染药
单核细胞增生李斯特菌
食品安全
食品加工
作者
Akansha Prasad,Shadman Khan,Fatima Arshad,Hareet Sidhu,Kyle Jackson,Roderick Maclachlan,Ekaterina Kvitka,Veronica Grignano,Hannah Mann,Carlos D. M. Filipe,Zeinab Hosseinidoust,Tohid F. Didar
出处
期刊:Science Advances
[American Association for the Advancement of Science]
日期:2025-10-29
卷期号:11 (44): eadx6918-eadx6918
被引量:1
标识
DOI:10.1126/sciadv.adx6918
摘要
Antibacterial additive use has surged because of rising incidences of food contamination despite concerns over antibiotic resistance. Bacteriophage (bacterial viruses) is a promising alternative with pathogen-level specificity. However, their commercial success has been limited by the considerable diffusion barriers they face within food, preventing effective delivery at contamination sites. Here, we introduce bacteriophage-loaded microneedle patches that enable targeted phage delivery directly within food, eliminating internal pathogens in a minimally disruptive manner. The application of microneedles within food is first explored. The platform is then substantiated by comparing performance in raw beef and cooked chicken, where we achieved up to 3-log reduction in Escherichia coli, meeting regulatory limits. In contrast, conventional surface application of the same phage failed to provide statistically significant decontamination. To ensure broad applicability, phage cocktails were also loaded into microneedles to demonstrate polymicrobial decontamination. This platform can also be adapted to extend food shelf-life by targeting spoilage-inducing bacteria.
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