卡德西尔
白质脑病
神经影像学
疾病
医学
脑淀粉样血管病
病因学
病态的
冲程(发动机)
儿科
病理
神经科学
生物信息学
痴呆
心理学
精神科
生物
机械工程
工程类
作者
Mikako Enokizono,Ryo Kurokawa,Akira Yagishita,Yasuhiro Nakata,Sho Koyasu,Hiroshi Nihira,Shigeko Kuwashima,Noriko Aida,Tatsuo Kono,Hiromu Mori
标识
DOI:10.1007/s11604-023-01493-0
摘要
Cerebral small vessel disease (cSVD) refers to a group of pathological processes with various etiologies affecting the small vessels of the brain. Most cases are sporadic, with age-related and hypertension-related sSVD and cerebral amyloid angiopathy being the most prevalent forms. Monogenic cSVD accounts for up to 5% of causes of stroke. Several causative genes have been identified. Sporadic cSVD has been widely studied whereas monogenic cSVD is still poorly characterized and understood. The majority of cases of both the sporadic and monogenic types, including cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), typically have their onset in adulthood. Types of cSVD with infantile and childhood onset are rare, and their diagnosis is often challenging. The present review discusses the clinical and neuroimaging findings of monogenic cSVD from the prenatal to adolescent period of development. Early diagnosis is crucial to enabling timely interventions and family counseling.
科研通智能强力驱动
Strongly Powered by AbleSci AI