自发交替
工作记忆
交替(语言学)
神经认知
空间记忆
任务(项目管理)
T型迷宫
巴恩斯迷宫
干涉理论
心理学
认知
认知心理学
空间学习
计算机科学
听力学
神经科学
医学
海马体
语言学
哲学
管理
经济
作者
Lisa Allen,Debra A. Murphy,Vanessa Roldán,M. N. H. Moussa,A. J. Draper,Alfredo Oliva Delgado,Maíra Aguiar,Miriam Abreu Capote,Timothy J. Jarome,K. H. Lee,Aaron T. Mattfeld,Randall S. Prather,Timothy A. Allen
摘要
Pigs are an important large animal model for translational clinical research but underutilized in behavioral neuroscience. This is due, in part, to a lack of rigorous neurocognitive assessments for pigs. Here, we developed a new automated T-maze for pigs that takes advantage of their natural tendency to alternate. The T-maze has obvious cross-species value having served as a foundation for cognitive theories across species. The maze (17' × 13') was constructed typically and automated with flanking corridors, guillotine doors, cameras, and reward dispensers. We ran nine pigs in (1) a simple alternation task and (2) a delayed spatial alternation task. Our assessment focused on the delayed spatial alternation task which forced pigs to wait for random delays (5, 60, 120, and 240 s) and burdened spatial working memory. We also looked at self-paced trial latencies, error types, and coordinate-based video tracking. We found pigs naturally alternated but performance declined steeply across delays (R2 = 0.84). Self-paced delays had no effect on performance suggestive of an active interference model of working memory. Positional and head direction data could differentiate subsequent turns on short but not long delays. Performance levels were stable over weeks in diverse strains and sexes, and thus provide a benchmark for future neurocognitive assessments in pigs.
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