Long-Term Efficacy of Dupilumab for the Treatment of Prurigo Nodularis: A Case Series

Prurigo nodularis is a chronic, pruritic dermatologic condition that results in nodule formation on the skin that is often treatment refractory and can impair quality of life. The underlying biological mechanism of prurigo nodularis formation is not completely understood, however, many affected patients have an underlying atopic diathesis. Existing therapies provide inadequate outcomes. Dupilumab has recently been approved for the treatment of prurigo nodularis, however, long term efficacy beyond one year has yet to be established. Here we present a series of four patients with prurigo nodularis that were successfully treated with dupilumab and maintained efficacy with a range of 26 months to 79 months.