癌症研究
膀胱癌
顺铂
肿瘤微环境
体内
癌细胞
癌相关成纤维细胞
肿瘤进展
癌症
医学
生物
内科学
化疗
生物技术
肿瘤细胞
作者
Tinghao Li,Kunyao Zhu,Hang Tong,Yan Sun,Junlong Zhu,Zijia Qin,Junrui Chen,Linfeng Wu,Xiaoyu Zhang,Aimin Wang,Xin Gou,Hubin Yin,Weiyang He
标识
DOI：10.1186/s13046-025-03487-4
摘要
The CXCL14/CCR7/STAT3 axis critically mediates cisplatin resistance in bladder cancer through dual modulation of DNA repair and glycolytic metabolism. Therapeutic cotargeting of this pathway with CCR7 or STAT3 inhibitors combined with cisplatin represents a promising strategy to overcome chemoresistance and improve clinical outcomes.
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(2025-6-4)
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