Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study

COA3, NFU1, and SARS2 significantly affect DPN risk, with COA3 lowering and NFU1 and SARS2 increasing risk. These findings highlight potential targets for DPN prevention and treatment, suggesting the importance of mitochondrial proteins in DPN pathogenesis, and providing new insights for future therapeutic strategies to effectively combat this debilitating condition.