Cyclopenta[bc]benzopyran Derivatives and Limonoids from Aglaia edulis with Cytotoxic and Anti-DENV Activity

Eighteen cyclopenta[b]benzopyran derivatives (1-5 and 11-23) and 10 limonoids (6-10 and 24-28) were identified from Aglaia edulis, including 10 undescribed compounds (1-10), all of which were identified by analysis of spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography studies. Nine compounds displayed significant cytotoxic activity against three cancer cells, with IC₅₀ values of 3-900 nM. Sixteen compounds demonstrated potent antiviral activity on the dengue virus, with selectivity index values between 13.0 and 532.6. A mechanism of action investigation revealed that compound 11 may function as an eIF4E activator, which could suppress the expression of the E protein, thereby conferring significant activity against the dengue virus.