皮肤类型
自愈水凝胶
材料科学
自愈
人造皮肤
伤口愈合
生物医学工程
复合材料
皮肤病科
高分子化学
医学
外科
病理
替代医学
作者
Yi Mao,Yajuan Sun,Cheng Yang
出处
期刊:Polymers
[MDPI AG]
日期:2024-03-03
卷期号:16 (5): 692-692
标识
DOI:10.3390/polym16050692
摘要
A dual biofunctional hydrogel (HQCS-SP) wound dressing, offering antibacterial properties and a biological response, was innovatively designed and developed to repair full-layer skin defects. The HQCS-SP hydrogel creates an artificial matrix that facilitates cell recruitment, extracellular matrix deposition, exhibiting exceptional tissue affinity, robust self-healing, effective hemostatic capabilities and accelerates wound healing. It is synthesized by crosslinking modified chitosan (HQCS) with spirulina protein (SP) and Fe3+. The HQCS provides antibacterial, antioxidant, good tissue affinity and excellent hemostasis performance. The incorporation of SP not only reinforces the antioxidant, antibacterial, anti-inflammatory, and pro-angiogenesis effects but also participates in the regulation of signal pathways and promotes wound healing. Therefore, this study offers a new visual angle for the design of advanced functional trauma dressings with great application potential in the bio-medical field.
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